Precise Predictions of Linear B Cell Epitopes in Protean 3D

B cell epitopes–the part of an antigen recognized by an antibody–are conformational in nature; however, accurately predicting these epitopes is difficult for proteins without a known three-dimensional (3D) structure. DNASTAR presents the NeoClone method, a machine learning approach that improves the ability to predict linear B cell epitopes (a peptide segment) using only sequence-based information. This method provides better overall predictive accuracy than COBEpro and Epitopia, two leading epitope prediction methods. Free trial software is available at dnastar.com.